Mitochondrial Support: NAD
What are Mitochondria?: They are cell components which are located outside the nucleus. They are composed of membranes and also contain DNA. A cell may contain up to 2000 mitochondrial structures.
Function: The major role is to produce energy and regulate the metabolism of the cell in order to fuel the functions of the cell. The energy currency of the cell os ATP, which is produced via glucose via NADH.
Mitochondria and the Aging Process: Aging is accompanied by a decline in mitochondrial function. Mitochondrial dysfunction has been associated with a wide range of physiologic alterations including: cell senescence and inflammation, as well as age-dependent decline in tissue and organ function. Current research now focuses on answering the question of what types of interventions can improve mitochondrial function and if these interventions can improve overall health and healthspan. Interventions ti improve mitochondrial function include physical exercise along with nutritional and supplement approaches. Regular physical exercise can benefit age related processes such as loss of muscle mass, and age related decline in cardiac and cognitive functions. This may act, at least partially, through stimulation of mitochondrial biogenesis in a variety of tissues.
Another approach to improve mitochondrial function has been to increase overall NAD levels. In mice, raising NAD levels in older mice appears to restore mitochondrial function. Approaches to increase NAD levels include direct supplementation or by altering NAD metabolism.
The Question Remains in Humans: Can reversal of the decline in mitochondrial function slow age related organ dysfunction and improve healthspan.
Supplement Resources: As we age, levels of NAD fall. NAD support may lead to a prolonged health span. Elevating NAD levels in mice can slow down the aging process and help them to love longer. The question remains if these results can be translated into humans. There is one supplement on the market from the company ELYSIUM that has been demonstrated in a randomized trial to increase NAD levels in humans.
BASIS from ELYSIUM contains:
Nicotinamide Riboside, 250mg
A direct precursor to the coenzyme NAD.
A bioavailable polyphenol similar to resveratrol, but more bioavailable. Pterostilbene is created by plants to protect against internal and external stresses.